At a glance
StatusResearch-use / not approved for human use
FDA approvedNo / not established
Human evidenceLimited
Last evidence reviewOctober 2026
Human evidence
Preclinical evidence
Long-term safety evidence
Most available support is preclinical, mechanistic or anecdotal. Human efficacy and long-term safety are not established.
Overview
Humanin is a mitochondrial-derived peptide (like MOTS-c) studied for cytoprotective, metabolic, and aging-related effects. It is a topic of interest in longevity research.
How It's Thought to Work
Research suggests humanin has cytoprotective signaling roles and may influence metabolism, insulin sensitivity, and cellular stress responses.
What the Research Says
Evidence is largely preclinical, with observational human data linking higher levels to certain aging outcomes. Clinical use is early and investigational.
Key studies to start with
Regulatory & Legal Status
Not approved by the FDA for human use. Sold as a research chemical.
Safety Considerations
Limited human safety data; unregulated product quality. Consult a qualified clinician.