Overview
KPV is a small tripeptide (lysine-proline-valine) derived from the end of alpha-melanocyte-stimulating hormone, studied primarily for anti-inflammatory effects, including in the gut and skin.
How It's Thought to Work
Research suggests KPV can enter cells and reduce inflammatory signaling (including NF-kB pathways), without the pigmentation effects of the larger melanocortin peptides.
What the Research Says
Evidence is largely preclinical (cell and animal models) on colitis and wound healing. Human clinical evidence is early.
Regulatory & Legal Status
Not approved by the FDA for human use. Sold as a research chemical.
Safety Considerations
Limited human safety data; unregulated product quality. Consult a qualified clinician.