Overview
MOTS-c is a mitochondrial-derived peptide (encoded within mitochondrial DNA) studied for roles in metabolic regulation, insulin sensitivity, and exercise adaptation. It is a popular topic in longevity circles.
How It's Thought to Work
Research suggests MOTS-c influences metabolic pathways (including AMPK signaling) and may act as a signal between mitochondria and the rest of the cell.
What the Research Says
Mostly preclinical (animal and cell) research on metabolism and aging. Human clinical evidence is early.
Regulatory & Legal Status
Not approved by the FDA for human use. Sold as a research chemical.
Safety Considerations
Limited human safety data; unregulated product quality. Consult a qualified clinician.